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MOTS-c dosing in clinical settings is based on extrapolation from mouse pharmacology (5 mg/kg in mice, allometrically scaled)
Some individuals may experience mild injection-site reactions (e.g., redness, swelling) or occasional headaches
This article examines what the evidence says about their effectiveness and what healthcare providers should know when considering them as part of a clinical program
However, DIO mice switched from an obesity-promoting WD to an LD (regardless of treatment status) displayed several genera and phyla differences compared to obese and lean controls
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