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Symptom Monitoring: Even though serious adverse events did not occur in trials, individual monitoring for headache, gastrointestinal symptoms, or unusual effects allows for early detection of tolerability issues and appropriate management adjustments

They are also not suitable for anyone pregnant, breastfeeding or planning to conceive

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The data show an increase of some other oral diabetes medications during that time period, although to a lesser degree

Since delayed gastric emptying is the primary mechanism, interventions that facilitate digestion and reduce sulfur substrate availability can significantly improve symptoms