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Moreover, excessive reactive oxygen species (ROS) and inflammatory cytokines secreted from macrophages and other immune cells [e.g., interferon- (IFN) and tumor necrosis factor (TNF)] can arrest the anagen phase, driving premature telogen and catagen phases, inducing apoptosis in the follicular microenvironment, leading to miniaturization and reduced hair density [2, 4, 5]

In October 2024 the UK government, for example, estimated that obesity cost the UK health service more than 11 billion each year (UK Government)

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