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The gap between doing it correctly and doing it approximately comes down to three variables most SOPs never mention: the angle of needle insertion, the rate of bacteriostatic water addition, and the pressure differential you create inside the vial when drawing your first dose

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3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines