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While a balanced diet or oral supplements are often sufficient for maintaining adequate B12 levels, certain conditions may necessitate vitamin B12 injections

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Users should discontinue use if they experience any signs of allergic reactions, such as redness, hives, or itchiness.[3] While copper can potentially cause skin irritation or toxicity, in vitro studies suggest that GHK-Cu complexes may have a lower likelihood of inducing these effects.[4] However, it is recommended to consult a healthcare professional before using any new product on the skin or scalp

This established the mechanistic rationale for NNMT inhibition