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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]
Using a 90-degree angle without sufficient tissue depth risks injecting into muscle
As interest in beauty supplements continues to grow, so does curiosity around the innovative ingredients behind them
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