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MS3 precursors were fragmented by HCD and analyzed using the Orbitrap (collision energy 55%, AGC 1.5E5, maximum injection time 120 ms, resolution was 50,000)
doi: 10.3389/fnsys.2021.698240 436 JohnsonC
Nerve damage is thought to affect up to half of people with diabetes
There is no published long-term off-drug follow-up for cagrilintide monotherapy (phase 2 only tracked 6 weeks post-treatment), but every drug in this class shows partial weight regain after stopping, and the REDEFINE 1 authors state outright that long-term treatment will probably be required to sustain the benefit
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