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Glucose is a substrate for lipogenesis, and either dietary intake of glucose and fructose or hyperglycemia due to T2DM-associated insulin resistance can lead to hepatic de novo lipogenesis
In the study by Ricciolini and colleagues, labelled [U- 14 C]glucose was not incorporated into PUFAs, unlike [1- 14 C]-acetylcarnitine [109], indicating that the formation of acetyl groups from pyruvate in mitochondria ensures complete metabolism
Most participants who experienced nausea during the initial titration phase reported significant improvement or complete resolution by weeks 4 to 8 at a stable dose
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