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Therefore, the ferritinophagy pathway is one of the targets for increasing the sensitivity of tumor cells to ferroptosis [36]

Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways

At the moment, there is no evidence that necroptosis of erythrocytes is associated with the release of DAMPs

When a single peptide is used to push a single pathway aggressively, the body can respond with counter-regulation