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It is unclear if the increased risk of NAION is specific to semaglutide or also true of other GLP-1 receptor agonist drugs, the study authors wrote in their paper
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[41] [42] The hypothesis that melatonin synthesis occurs within mitochondria and chloroplasts suggests an evolutionary and functional significance of melatonin in cellular energy metabolism and defense mechanisms against oxidative stress, reflecting the molecule's ancient origins and its multifaceted roles across different domains of life
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