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What the Current Clinical Evidence Shows Phase 2 trial data published in the NEJM in 2023 show gastrointestinal events including nausea were the most common side effects, were transient and self-limiting in most participants, and were more frequent at higher doses
Obesity, dyslipidemia, and cardiovascular disease: a joint expert review from the Obesity Medicine Association and the National Lipid Association 2024
Tolerance and dose creep Some long-term users report that a previously effective dose becomes less potent over time
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