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How often and when you feel these symptoms gives your doctor the context they need to tell the difference between temporary adjustment symptoms and patterns that need attention

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The unique side effect is dysesthesia tingling or altered skin sensation affecting up to 20.9% of patients at the highest dose

In comparison, the STEP-1 trial reported that 2.4mg/weekly semaglutide led to side effects in 89.7% of the subjects, with the most common complaints being [17]: Nausea (44.2% of subjects) Diarrhea (31.5%) Vomiting (24.8%) Constipation (23.4%) Dyspepsia (10.3%) Abdominal pain (10% Gallbladder-related events (2.6%) The majority of gastrointestinal reactions were of mild to moderate intensity, temporary, and resolved without needing a permanent halt in treatment