For example, most major GLP-1 trials have enrolled people with obesity or diabetes
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In the recently published BARI-OPTIMISE double-blind, placebo-controlled trial, 70 patients post-SG or RYGB who were tested and found to have insufficient GLP-1 response to meal stimulation were randomized to receive liraglutide (3 mg/day) or placebo, in addition to lifestyle interventions [49]
This enhanced efficacy is due to semaglutides ability to achieve greater receptor activation, amplifying appetite suppression and promoting a caloric deficit