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If you compare someones body composition before and after weight loss, its generally better after. Also making recent headlines is Ozempic face, or the tendency to have a saggy or sunken-in facial appearance after being on GLP-1 drugs
There are GLP-1 receptors in all types of brain cells, and they exhibit neuroprotective properties
Pastornicka A, Rybarova S, Drahosova S, et al
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Cancers (Basel) (2014) 6(3):144163
Evidence-based levers that reliably move the needle: A sustainable calorie deficit with adequate protein Resistance training plus daily movement Sleep and stress management (often underestimated) Clinician-guided options when appropriate, including FDA-approved obesity medications (e.g., Wegovy and Zepbound ) and weight loss injections A good rule of thumb: don't outsource a fundamentals problem to an unproven tool
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