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We also assess the potential mechanisms that contribute to the reduction in major adverse cardiovascular events in individuals treated with GLP1R agonists and highlight the emerging cardiovascular biology of novel GLP1-based multi-agonists currently in development
This prevents unnecessary concern over a false positive for kidney impairment
Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor itself the target of every compound in this class), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (linked to glucose homeostasis and GLP-1 secretion) describe the metabolic terrain a clinician is prescribing into
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