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For many patients, evidence-based approaches such as cognitive behavioral therapy for insomnia, circadian rhythm support, medication review, sleep apnea screening, mental health treatment, and lifestyle changes may be more appropriate than experimental peptide therapy

The 2024 Stanford study provided stark evidence of this, noting that the mitochondrial calcium to SOD2 (a protective enzyme) ratio was elevated by 1.67x in Long COVID donors and 1.75x in ME/CFS donors compared to healthy controls