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Some researchers prefer this option during the initial low-dose escalation phase, then switch to a higher concentration for maintenance dosing
For example, KMO deficiency in male mice elevates KYNA and induces depressive-like behaviours via 7nAChR antagonism, impairing cholinergic modulation of prefrontal circuits, effects that are reversed by restoring 7nAChR signalling [71]
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This allows for optimal absorption before the digestive system becomes busy with meals
Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, et al: Global strategy for asthma management and prevention: GINA executive summary
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