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The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration
Channels created by microneedling begin closing within minutes
A patient who vomits within 2 hours of taking cyclosporine, tacrolimus, warfarin, or an oral contraceptive has effectively missed that dose
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