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Additionally, tirzepatide activates GLP-1 receptors on vagal afferent neurons in the gastrointestinal tract, which transmit satiety signals to the nucleus tractus solitarius in the brainstem, subsequently influencing hypothalamic appetite centers

These could include improvement in endothelial function, reduction in oxidative stress, and potential antiatherosclerotic effects

Hormonal Feedback Loops : Disrupted sleep also dysregulates ghrelin (the hunger hormone) and leptin (the satiety hormone), potentially undermining metabolic goals

More broadly it says to disclose all supplements and herbal products, and to bring current GI symptoms and recent lab work into that conversation before adding anything

Remember, this journey is about making sustainable changes over time