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This strategy has been applied to dulaglutide, where two GLP-1 molecules are fused to the Fc fragment of IgG4, increasing the half-life while reducing the renal elimination due to the increased molecular weight

Hopkins Tanne J, Wegovy: FDA approves weight loss drug to cut cardiovascular risk

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Oltre che negli Stati Uniti e nell'Unione Europea, Mounjaro (tirzepatide) approvato anche in Canada, Regno Unito, Australia, Giappone, Svizzera, India, Cina e Sudafrica

However, in senescent CD8 T cells, autophagy is not restored despite reduced mTORC1 activity, partly due to alternative inhibitory mechanisms such as chronic p38 MAPK activation, which impairs autophagy independently of mTORC1 and contributes to immune decline in senescent CD8 T cells