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Two molecules anchor this story, and they are usefully understood as a pair: tirzepatide, which proved that adding a second incretin receptor to the mix yields more than additive benefit, and retatrutide, which adds a third and approaches the magnitude that previously required a surgeon
Injections are usually prescribed for a diagnosed deficiency, sometimes for life, as in pernicious anemia or after stomach surgery
Oral semaglutide is the active ingredient in Rybelsus, a once-daily tablet
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