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PubMed, Lundgren, Julie R., et al
Unlike the combinatorial therapy of G-protein-coupled receptor-based peptide dual agonists, such as GLP-1/glucagon, these peptidyl nuclear hormone conjugates require additional consideration for differential pharmacodynamics where time action for clearance of each activity is inherently dissimilar
Access this article Similar content being viewed by others Abbreviations CHEK2 gene: Checkpoint kinase DNA: Deoxyribonucleic Acid DIO: Iodothyronine deiodinases EFSec: Elongation factor of Sec GPx: Glutathione peroxidases MSRB1: Methionine-R-sulfoxide reductase 1 NIS: Sodium-iodide symporter PACAP: Pituitary adenylate cyclase-activating polypeptide PCR: Polymerase chain reaction PCR-RFLP: Polymerase chain reaction-restriction fragment length polymorphism Pax8: Paired box 8 ROS: Reactive oxygen species Selenium: Se Se-protein: Selenoprotein Sec: Selenocysteine SECIS: Selenocysteine-insertion sequence SBP2: SECIS Binding protein SELENOP1 or SePP1: Selenoprotein P1 SEPN1: Selenoprotein N SELENOS: Selenoprotein S SEPSECS: Selenocysteine synthase SNP: Single nucleotide polymorphism SEPHS2: Selenophosphate synthetase 2 TXNRD: Thioredoxin reductases TXNRD2: Thioredoxin reductase 2 T4: Thyroxine T3: Triiodothyronine TSH: Thyroid stimulating hormone TRAb: TSH receptor autoantibodies TPOAb: Antithyroperoxidase antibody TgAb: Antithyroglobulin antibodies ThyPRO: Thyroid patient-reported outcome TXNRD1: Thioredoxin/thioredoxin reductase-1 References Varlamova EG, Cheremushkina IV (2017) Contribution of mammalian selenocysteine-containing proteins to carcinogenesis
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