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Of these, MALA is the rare and most severe form, with a mortality rate of up to 50%
First, an amino acid substitution at position 8 (alanine replaced with aminoisobutyric acid) provides resistance to DPP-4 degradation, the primary enzyme responsible for native GLP-1 breakdown
Mouse liver tissues were fixed in 4% paraformaldehyde solution at 37C for 24 h and embedded in paraffin, then sectioned at 5 m thickness
Research published in a 2025 narrative review found that GLP-1 medications can lead to muscle loss, micronutrient deficiencies, and digestive disruptions if nutritional needs aren't actively managed
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