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The injections optimise one pathway but are not the driver of sustained weight maintenance

That said, medications causing depression isnt something unique to GLP-1s, since many drugs can impact your brains chemistry

However, data from clinical trials suggest the following: People with diabetes who take a GLP-1 peptide in addition to diet and exercise changes can expect to lose 4% to 6% of their body weight

Given the complex mechanisms at play, it may be that in the overall population of adults with diabetes, GLP-1 RAs have minimal effects on GFR but may be more beneficial within specific subpopulations

This mechanism supports both chronic weight management and blood sugar control