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Centenarians have plasma MOTS-c levels resembling those of people decades younger, suggesting preserved mitochondrial signaling is a feature of exceptional aging

Body composition substudy analyses using DXA scanning reveal the proportion of lean mass loss to total weight loss with Retatrutide treatment remains similar to other obesity pharmacotherapies, providing reassurance that enhanced weight loss does not translate to disproportionate muscle loss

The approval of Wegovy was a significant milestone in metabolic medicine

The longer-term implications are more sobering

With up to 14% weight loss over 48 weeks in Phase 3 trials and a favorable safety profile, it may represent an effective treatment option for adolescents, particularly those with lipid-driven metabolic disturbances