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The protocol for this study was approved by a suitably constituted independent ethics committee (Ethics Committee of Peking University Third Hospital, Beijing, China)
The researchers identified PEN2 as a metformin binding partner that forms a complex with ATP6AP1, leading to AMPK activation through inhibition of the lysosomal v-ATPase
GLP-1 slows gastric emptying, which prolongs that feeling of fullness
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