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Patients with suspected hypercortisolism require appropriate endocrine evaluation according to Endocrine Society guidelines, typically including at least two abnormal screening tests (24-hour urinary free cortisol, late-night salivary cortisol, or low-dose dexamethasone suppression testing) before confirmatory testing and specialist referral

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If you look at the patient information leaflet for these medications, you will see a prominent warning regarding "thyroid C-cell tumours." Rodent Studies vs

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But it almost certainly reduces the gastrointestinal rebound effects that some researchers report after abrupt cessation, including paradoxical increases in appetite, changes in bowel habits, and blood sugar fluctuations