Specifically, compared with persisting GLP-1RA, the addition of basal insulin by either free up-titration or FRC caused an additional decrease of 0.75% and 36.3 mg/dl in HbA1c and FPG, respectively, and a 7.59 times higher risk of hypoglycemia in 26 weeks
To get and maintain your weight loss results or blood sugar control, you may need to stick with the medication long-term
A 260-pound man can maintain a 500-calorie deficit while still eating 2,400 calories, enough to support substantial protein intake, diverse nutrition, and adequate energy for daily life
Weight cyclinglosing weight then regaining it rapidlycreates additional metabolic stress that may increase future weight gain risk
Tirzepatide (Zepbound) : In the SURMOUNT-4 trial, participants who stopped tirzepatide after losing about 21% of their body weight regained an average of 14% over the following year