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Few small RCTs suggested histological improvements in terms of hepatocellular inflammation (especially ballooning) and beneficial effects on liver fibrosis [103106]

Number of participants with prediabetes (a and b) or normoglycemia (c and d) at baseline and evaluable data at week 104

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To exclude the possibility that GSH is cleaved by enzymes to release glutamate for Ca signal propagation, we employed GGsTop, a well-known chemical inhibitor that specifically targets gamma-glutamyl transpeptidase (GGT), the enzyme responsible for converting GSH to Glu 26