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At the top, an L-lysine residue within a peptide is methylated by a methyltransferase using S-adenosylmethionine as a methyl donor, forming - N -trimethyllysine

Similarly, in myocardial ischemia-reperfusion, 3-AB suppressed PARP1 activation, reduced infarct size, and improved cardiac function 174

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However, these parameters derive entirely from animal studies, and optimal human administration strategies remain undefined