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also known as myostatin) and activin A (ActA) are the two major ligands mediating the muscle-minimization actions of ActRIIA/B receptors 22,26,27,28,29,30

Most efficacy signals summarized in this review arise from preclinical models

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( g ) Representative image of two-photon AP brain slice (n = 3 slices, 3 mice) from a SemaTRAP:soma-GC8s mouse with soma-GC8s expressing cells in green