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CntA/B is a notoriously hard enzyme to study, but once it was stabilized, we were able to gain insight into how CntA perceives its L-carnitine substrate with a 3D crystal structure model, and by studying the complete electron transfer pathway, we could see how the protein is able to turn over TMA

These demonstrated short-term safety in adults with normal renal and hepatic function

Proc Natl Acad Sci USA 94:27452750

this could be due to a lack of understanding regarding its mechanisms, as well as the fact that over the past two decades, only a handful of studies have researched the peptide (many from the same laboratory or group)

Neuron 69, 664679