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In addition, their poor water solubility leads to instability in biological culture medium, and low serum stability and limited cell uptake further damage pharmacokinetic properties and bioavailability, eventually leading to non-specific distribution to normal tissues and treatment failure [31,32,33]
This is why the conversion charts in this guide exist
A large number of preclinical and clinical studies support the view that PYY system dysfunction is an important part of the pathogenesis of obesity, insulin resistance, and type 2 diabetes
Final treatment options are confirmed during the medical consultation