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To selectively activate endogenous GLP-1producing NTS neurons that project to the VTA, the retrogradely infecting virus canine adenovirus-2expressing Cre recombinase (CAV2-Cre) was infused into the VTA, and a Cre-dependent virus expressing a neural activating DREADD [AAV-DIO-hM3D(Gq)-mCherry] was infused into the NTS (Fig

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Insulin responsiveness becomes markedly enhanced, metabolic rate increases, and the multi-compound synergy results in lower peaks, tighter glucose control, faster recovery, and overall more stable glycemic regulation