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MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer
Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 ( In an experimental model of abdominal aortic aneurysm, topiramate markedly downregulated pro-inflammatory M1 macrophage activity, reduced the expression of TNF-, IL-1, and matrix metalloproteinase-9, and promoted a phenotypic shift of macrophages from M1 to M2, thereby mitigating pro-inflammatory activity and enhancing tissue repair processes ( These studies collectively suggest that topiramate exerts significant neuroprotective effects across various pathological models through its potent anti-inflammatory properties
Signs You May Want to Pause or Stop If you notice headaches, irritability, trouble sleeping, or nausea after taking this, you're taking too much or too often
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