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it occurs in approximately 1 out every 700800 live births [60]
This results in a leaner, more toned physique
In the meantime, other well-studied protocols already exist to target these same hallmarks of aging, ranging from pharmacological approaches like rapamycin and SGLT-2 inhibitors to lifestyle strategies such as exercise and caloric restriction
The presence of these factors leads to the activation of pathogenic ERS and impairs the proper functioning of the unfolded protein response (UPR) pathway
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