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Therapeutic implications Based on the data above, the first ever randomized, double blinded, placebo controlled clinical intervention trial registered with the World Health Organization involving high dose B1 therapy was conducted by Dr.Saadia ShahzadAlam of the Pharmacology Deptt (Co-Principal Investigator 1) of Federal Postgraduate Medical Institute Lahore for a period of 5 months to study the effect of high dose thiamine therapy on biochemical profile and activities of thiamine dependant enzymes on type 2 diabetics in the Pakistani population

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