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ABCG2 and ABCC4 utilize ATP hydrolysis to expel uric acid from the cell, and the urate efflux mediated by both depends on the intracellular urate concentration [80, 81]

Adverse reactions became more frequent, while intentional or non-therapeutic cases stayed rare

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Unlike topical creams or oral supplements, transdermal patches provide targeted and sustained release of glutathione directly into the bloodstream

RPE is particularly susceptible to oxidative stress due to its role in phagocytosis of photoreceptor outer segments 2