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To enhance the effect of leptin analogues, amylin mimetics such as pramlintide have been used in combination with metreleptin

The majority of patients were White (81%) and 60% were male

Glucagon-like peptide-1 agonist drugs, such as semaglutide, could save countless lives at risk due to diabetes and obesity

Unlike synthetic GH injections, peptide therapy works gradually and naturally, encouraging the body to self-regulate hormone production for long-term benefits

Additionally, the cyclic trisulfide structure of LASSS, as opposed to the linear trisulfides such as GSSSG and cysteine trisulfide (Cys-SSS-Cys), could guarantee the unique reactivity of LASSS (see again Figure 1a for chemical structures)