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Third, GLP-1 receptor agonists (particularly the shorter-acting agents) delay gastric emptying, thus delaying carbohydrate absorption and promoting satiety

It also stimulates the transcription factor CREB, increasing insulin gene expression and biosynthesis to maintain secretory capacity (Zheng et al., 2024)

The long-term effects of chronic use on the endocrine system have not been formally investigated

Think of the drug as water in a set of interconnected tanks, where tank size and valve speed vary by person, so the emptying schedule differs accordingly

The density for this water was weaker than that of the ligand, although strong enough to warrant modelling (Supplementary Fig