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This once-weekly injectable medication works through multiple mechanisms to enhance insulin secretion, suppress glucagon, and promote weight loss
The link between the medications and cancer risk could be due to weight loss, since having overweight or obesity is linked to a higher cancer rate, or it could be from the impact GLP-1s have on certain pathways in the body
The modified treatment-regimen estimand represents the estimated average treatment effect regardless of adherence to study intervention or initiation of prohibited weight management treatments, and assuming participants who took rescue orforglipron would not have received any additional improvement from their randomized study treatment
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