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Liraglutide administration prevented the decrease of AKT and GSK-3 phosphorylation after treated A 1-42 protein, which inhibiting tau hyperphosphorylation (164, 211)
The hyperglycemia-related increased proximal tubular sodium reabsorption results in lower sodium levels at the level of the macula densa increasing GFR via inhibiting TGF, further augmenting the amount of filtered and reabsorbed sodium with increased ATP demands
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