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6,8 Studies looking at higher doses, such as one comparing 12.5mg, 25mg, and 50mg, found a non-dose-dependent steady-state level maximum at the 25mg dose

This dual dysfunction of microglia and astrocytes leads to extensive oxidative stress, immune activation, and eventual neuronal degradation

However, these observations have not been confirmed in large-scale human trials

Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Materials, further inquiries can be directed to the corresponding authors

Rather than flushing this food waste with enemas, its better to eat a diet that promotes a healthy gut microbiome [49+, 50]