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In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (Kastin et al., 2002
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It has been reported that AC dose dependently inhibits tyrosinase activity, the main enzyme controlling melanin synthesis, and melanin production in B16 melanoma cells through the inhibition of adenyl cyclase and -melanocyte stimulating hormone (-MSH) (Song and Sim 2009)
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