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10.1210/en.2013-1142 84
Similar to other GLP-1RAs, tirzepatide was associated with mild to moderate gastrointestinal side effects
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Those are FDA-approved tirzepatide products manufactured by Eli Lilly
The strategic logic is straightforward: even if a biosimilar manufacturer can replicate the antibody sequence after the composition patent expires, it cannot replicate a specific dosing regimen covered by a valid method-of-use patent, or a specific prefilled syringe design covered by a device patent, without infringement risk
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