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Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet
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A 40-week clinical trial (SUSTAIN FORTE) was conducted at 125 outpatient clinics across 10 countries, which involved 961 adults with type 2 diabetes who had uncontrolled diabetes with metformin (with or without sulfonylurea)
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