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In vitro studies on human mononuclear cells also showed that alogliptin (0.5, 1 and 5 nM) treatment for 24 h exhibited a decrease in TLR-4 mediated increase in IL-1 and IL-6 [55]
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If a patient receives a dosage significantly higher than advised, serious side effects like renal failure or blood poisoning may manifest
Quantitative real-time polymerase chain reaction RNA extraction was performed using the RNeasy Mini Kit and the DNAse Kit (Qiagen)
Higher doses have higher efficacy, but they also increase the risk of gastrointestinal side effects
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