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Tirzepatide , marketed as Mounjaro, builds on this by targeting two receptors : GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)
it demonstrates significant efficacy in weight loss
If supportive measures such as supplementation, topical therapy, or sun protection are discontinued, pigmentation may gradually recur
Reduced glucagon production lowers blood glucose levels
Additionally, diabetes-related complications such as diabetic neuropathy, cardiovascular disease, or kidney impairment can contribute to persistent fatigue
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