which one is tirzepatide has a quirk built into the molecule: instead of acting on target, it activates two receptors at once — GIP and GLP-1. That's why it's called a dual agonist. The Tirzepatide Explained: The Future of

Conflicts of interest: The authors declare no conflicts of interest

a lot of competitors

review at 4 mg, 9 mg, 12 mg Best For Mirrors current Phase 3 maintenance arms Approach Slow titration Duration Add 2-4 weeks per dose step when GI symptoms persist Review Point Each dose step Best For When nausea, vomiting, or diarrhea is hard to tolerate Trial protocols allowed participants to stay at the current dose for an extra 2-4 weeks when GI side effects were significant

Details For Those Who Want To Dive Deeper: Semaglutide and Cardiovascular Risk: What the Evidence Shows Semaglutide, a medication originally developed for weight management and diabetes treatment, has emerged as a powerful tool for reducing cardiovascular risk

Rev Endocr Metab Disord 23(3):52139 Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S et al (2023) Semaglutide and cardiovascular outcomes in obesity without diabetes