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For severe infection or failure of empirical treatment, fluoroquinolone (if not used for initial treatment), piperacillin/tazobactam, third-generation cephalosporin/enzyme inhibitor, carbapenem (imipenem, meropenem, or biapenem), or combination treatment with glycopeptides is the preferred choice [64, 67]

The peptides ability to produce metabolic effects with such rapid plasma clearance (3-minute half-life) while maintaining prolonged biological activity represents a significant knowledge gap requiring further investigation

(13) The murine models were divided into six groups, where the control group was presented with a placebo and the rest with DSIP

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